Article: Static and extremely low frequency electromag... [J Cell Biochem. 1993] - PubMed - NCBI

Static and extremely low frequency electromag... [J Cell Biochem. 1993] - PubMed - NCBI
http://www.ncbi.nlm.nih.gov/pubmed/8098713

---

• Abstract

J Cell Biochem. 1993 Apr;51(4):394-403.

Static and extremely low frequency electromagnetic field exposure: reported effects on the circadian production of melatonin.

Reiter RJ.

Source

Department of Cellular and Structural Biology, University of Texas Health Science Center, San Antonio 78284-7762.

Abstract

The circadian rhythm of melatonin production (high melatonin levels at night and low during the day) in the mammalian pineal gland is modified by visible portions of the electromagnetic spectrum, i.e., light, and reportedly by extremely low frequency (ELF) electromagnetic fields as well as by static magnetic field exposure. Both light and non-visible electromagnetic field exposure at night depress the conversion of serotonin (5HT) to melatonin within the pineal gland. Several reports over the last decade showed that the chronic exposure of rats to a 60 Hz electric field, over a range of field strengths, severely attenuated the nighttime rise in pineal melatonin production; however, more recent studies have not confirmed this initial observation. Sinusoidal magnetic field exposure also has been shown to interfere with the nocturnal melatonin forming ability of the pineal gland although the number of studies using these field exposures is small. On the other hand, static magnetic fields have been repeatedly shown to perturb the circadian melatonin rhythm. The field strengths in these studies were almost always in the geomagnetic range (0.2 to 0.7 Gauss or 20 to 70 mu tesla) and most often the experimental animals were subjected either to a partial rotation or to a total inversion of the horizontal component of the geomagnetic field. These experiments showed that several parameters in the indole cascade in the pineal gland are modified by these field exposures; thus, pineal cyclic AMP levels, N-acetyltransferase (NAT) activity (the rate limiting enzyme in pineal melatonin production), hydroxyindole-O-methyltransferase (HIOMT) activity (the melatonin forming enzyme), and pineal and blood melatonin concentrations were depressed in various studies. Likewise, increases in pineal levels of 5HT and 5-hydroxyindole acetic acid (5HIAA) were also seen in these glands; these increases are consistent with a depressed melatonin synthesis. The mechanisms whereby non-visible electromagnetic fields influence the melatonin forming ability of the pineal gland remain unknown; however, the retinas in particular have been theorized to serve as magnetoreceptors with the altered melatonin cycle being a consequence of a disturbance in the neural biological clock, i.e., the suprachiasmatic nuclei (SCN) of the hypothalamus, which generates the circadian melatonin rhythm. The disturbances in pineal melatonin production induced by either light exposure or non-visible electromagnetic field exposure at night appear to be the same but whether the underlying mechanisms are similar remains unknown.

PMID:

8098713

[PubMed - indexed for MEDLINE]

Supplemental Content

Related citations

• Inconsistent suppression of nocturnal pineal melatonin synthesis and serum melatonin levels in rats exposed to pulsed DC magnetic fields. [Bioelectromagnetics. 1998]
  Inconsistent suppression of nocturnal pineal melatonin synthesis and serum melatonin levels in rats exposed to pulsed DC magnetic fields.

  Reiter RJ, Tan DX, Poeggeler B, Kavet R. Bioelectromagnetics. 1998; 19(5):318-29.
• Electric field exposure alters serum melatonin but not pineal melatonin synthesis in male rats. [Bioelectromagnetics. 1994]
  Electric field exposure alters serum melatonin but not pineal melatonin synthesis in male rats.

  Grota LJ, Reiter RJ, Keng P, Michaelson S. Bioelectromagnetics. 1994; 15(5):427-37.
• Sinusoidal 50-Hz magnetic fields depress rat pineal NAT activity and serum melatonin. Role of duration and intensity of exposure. [Life Sci. 1995]
  Sinusoidal 50-Hz magnetic fields depress rat pineal NAT activity and serum melatonin. Role of duration and intensity of exposure.

  Selmaoui B, Touitou Y. Life Sci. 1995; 57(14):1351-8.
• Review [Evaluation of the effect of magnetic fields on the secretion of melatonin in humans and rats. Circadian study]. [Bull Acad Natl Med. 2002]
  Review [Evaluation of the effect of magnetic fields on the secretion of melatonin in humans and rats. Circadian study].

  Touitou Y, Selmaoui B, Lambrozo J, Auzeby A. Bull Acad Natl Med. 2002; 186(9):1625-39; discussion 1639-41.
• Review Melatonin suppression by static and extremely low frequency electromagnetic fields: relationship to the reported increased incidence of cancer. [Rev Environ Health. 1994]
  Review Melatonin suppression by static and extremely low frequency electromagnetic fields: relationship to the reported increased incidence of cancer.

  Reiter RJ. Rev Environ Health. 1994 Jul-Dec; 10(3-4):171-86.

See reviews… See all…

Cited by 5 PubMed Central articles

• The frequencies of micronuclei induced by cisplatin in newborn rat astrocytes are increased by 50-Hz, 7.5- and 10-mT electromagnetic fields. [Environ Health Prev Med. 2005]
  The frequencies of micronuclei induced by cisplatin in newborn rat astrocytes are increased by 50-Hz, 7.5- and 10-mT electromagnetic fields.

  Miyakoshi Y, Yoshioka H, Toyama Y, Suzuki Y, Shimizu H. Environ Health Prev Med. 2005 May; 10(3):138-43.
• Mechanisms of geomagnetic field influence on gene expression using influenza as a model system: basics of physical epidemiology. [Int J Environ Res Public Healt…]
  Mechanisms of geomagnetic field influence on gene expression using influenza as a model system: basics of physical epidemiology.

  Zaporozhan V, Ponomarenko A. Int J Environ Res Public Health. 2010 Mar; 7(3):938-65. Epub 2010 Mar 10.
• Emerging synergisms between drugs and physiologically-patterned weak magnetic fields: implications for neuropharmacology and the human population in the twenty-first century. [Curr Neuropharmacol. 2007]
  Emerging synergisms between drugs and physiologically-patterned weak magnetic fields: implications for neuropharmacology and the human population in the twenty-first century.

  Whissell PD, Persinger MA. Curr Neuropharmacol. 2007 Dec; 5(4):278-88.

See all…

Related information

Recent activity

• Static and extremely low frequency electromagnetic field exposure: reported effe…
  Static and extremely low frequency electromagnetic field exposure: reported effects on the circadian production of melatonin.

  J Cell Biochem. 1993 Apr ;51(4):394-403.
  PubMed
• Daytime 50 Hz magnetic field exposure and plasma melatonin and urinary 6-sulfato…
  Daytime 50 Hz magnetic field exposure and plasma melatonin and urinary 6-sulfatoxymelatonin concentration profiles in humans.

  J Pineal Res. 2001 Oct ;31(3):234-41.
  PubMed
• Magnetic fields and pineal function in humans: evaluation of nocturnal acute exp…
  Magnetic fields and pineal function in humans: evaluation of nocturnal acute exposure to extremely low frequency magnetic fields on serum melatonin and urinary 6-sulfatoxymelatonin circadian rhythms.

  Life Sci. 1996 ;58(18):1539-49.
  PubMed
• Chronic exposure to 60-Hz electric fields: effects on pineal function in the rat…
  Chronic exposure to 60-Hz electric fields: effects on pineal function in the rat.

  Bioelectromagnetics. 1981 ;2(4):371-80.
  PubMed
• 60-Hz electric-field effects on pineal melatonin rhythms: time course for onset …
  60-Hz electric-field effects on pineal melatonin rhythms: time course for onset and recovery.

  Bioelectromagnetics. 1986 ;7(2):239-42.
  PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

See more…

PreferencesTurn off

Ghostery has found the following on this page:Google Analytics
Quantcast